Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity

By |2021-08-13T08:11:02+00:00August 6th, 2021|

M. Corcoran et al., (2016) Nature Communications 7:13642, doi: 10.1038  Abstract Comprehensive knowledge of immunoglobulin genetics is required to advance our understanding of B cell biology. Validated immunoglobulin variable (V) gene databases are close to completion only for human and mouse. We present a novel computational approach, IgDiscover, that identifies germline V genes from expressed [...]